Abstract

Interleukin 1, IL-6, and tumor necrosis factor (TNF) are typical examples of multifumctional cytokines involved in the regulation of immune response, hematopoiesis and inflammation . The peripheral immune activation induces microglial cells and macrophages of the synthesis of pro-inflammatory cytokines. Both peripheral and intraventricular administration of these cytokines trigger central symptoms of acute phase reaction, including fever, activation of the hypothalamic-pituitary-adrenal axis and depression, as well as autoimmune diseases such as rheumatoid arthritis and mesangial proliferative glomerulonephritis.

Adres: mgr Katarzyna Czerwiec
e-mail: kasia0001@poczta.onet.pl